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ERITEMA INDURATUM BAZIN PDF

We describe two cases of erythema induratum of Bazin (EIB), a cutaneous form of TB. •. Cases had no signs of active TB, but had a positive Interferon Gamma. Erythema induratum is a panniculitis on the calves. It occurs mainly in women, but it is very rare defined pathogen. The medical eponym Bazin disease was historically synonymous, but it applies only to the tuberculous form and is dated. Erythema induratum (also referred to as erythema induratum of Bazin (EIB) or nodular vasculitis) is a chronic nodular skin disease that is thought to represent a .

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The ankle skin becomes sensitive to temperature changes. Bazin in was the first to describe erythema induratum as a benign erythematous scrofulid; however, it was not until after the discovery of the Mycobacterium tuberculid in that the term scrofulid became commonly associated with TB.

Prolonged, multidrug treatment is necessary to prevent relapse and avoid drug resistance, and progress may be slow. The disease preferentially affects the posterior and anterolateral aspects of the lower legs of women; however it can occur in other locations as well as in men and children. Hong Kong Med J.

Risk factors While there are no risk factors other than previous exposure to TB per se, cold weather, venous stasis with poor peripheral blood flow and obesity appear to precipitate the development of lesions.

Nonsteroidal antiinflammatory agents NSAIDS may alleviate discomfort associated with nodular or ulcerated lesions and should also be considered. Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more. Nonulcerated lesions heal with only postinflammatory hyperpigmentation, whereas ulcerated lesions may heal with atrophic, hyperpigmented scars. Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account.

Robbins and Cotran pathologic basis of disease 7th inxuratum. Patients may or may not recall a history of tuberculosis infection or exposure. In these situations, a high index of clinical suspicion is required. From Wikipedia, the free encyclopedia.

Erythema induratum of bazin.

The association between EIB and MTB was later questioned once more by additional reports of patients that presented with a similar clinical picture without positive tuberculin skin tests and no history of TB exposure. Which of the following best describes your experience with hand-foot-and-mouth disease? Characteristic findings on physical examination On physical examination, affected patients will frequently have heavy or column-like calves, erythrocyanosis, cutus marmmorata and some degree of venous insufficiency.

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There is a strong female predominance of the disease Other Early morning sputum, urine and gastric aspirates may be helpful to rule out an underlying active infection, but are generally negative.

Expected results of diagnostic studies No pathognomonic histologic feature of erythema induratum exists, and histologic findings may vary with the age of the lesion Figure 2.

Erythema induratum – Wikipedia

Get free access to newly published articles Create a personal account or sign in to: Our website uses cookies to enhance your experience. Feiwel, M, Munro, DD. Acquired generalized lipodystrophy partial: You can help Wikipedia by expanding it. Laboratory tests Additional laboratory tests including a complete blood count with differential, chemistry panel, erythrocyte sedimentation rate, and liver function tests are typically normal bazkn erythema induratum.

Treatment options for erythema induratum Medical Treatment Surgical Procedures Physical Modalities Anti-tuberculosis treatment rifampin, isoniazid, and pyrazinamide Not indicated Rest Non-steroidal anti-inflammatory agents Compression stockings Potassium iodide Supportive bandages Dapsone Oral gold salts Doxycycline. Historical context Until recently, clinicians long debated the pathogenesis of EIB and the aforementioned association with Indurathm tuberculosis.

What is the Cause of the Disease? Until recently, clinicians long debated the pathogenesis of EIB and the aforementioned association with Mycobacterium tuberculosis. This section is empty. There is still no indurafum as to whether venules, larger septal veins, or arterioles are most typically involved.

Subcutaneous nodule with infuratum poorly defined violaceous erythema on the posterior leg The plaques are generally erythematous and indurated, with an overlying scaly surface, and may or may not be tender to deep palpation. Active TB infections should be treated more aggressively than latent infections.

Caseation necrosis is a late finding evident in approximately one half of cases. Retrieved from ” https: A good rule of thumb is, if a patient presents with chronic, relapsing, ulcerating nodules demonstrating mostly lobular panniculitis, an assessment for latent and active TB is warranted.

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Erythema induratum also referred to as erythema induratum of Bazin EIB or nodular vasculitis is a chronic nodular skin disease that is thought to represent a hypersensitivity response to Mycobacterium tuberculosis or its antigens.

Although the majority of cases present with a lymphocytic idnuratum, it is not a diagnostic requirement; ie, the absence of vasculitis does not exclude the diagnosis of EIB in an otherwise appropriate clinical context.

Lesional morphology may range from deep seated areas of subcutaneous induration to well-defined plaques and nodules, characteristically on the posterior or lateral aspects of the lower legs Figure 1.

Early morning sputum, urine and gastric aspirates may be helpful to rule out an underlying active infection, but are generally negative. Views Read Edit View history. Chilblains may be present. The plaques are generally erythematous and indurated, with an overlying scaly surface, and may or may not be tender to deep palpation. The prognosis of erythema induratum is excellent with appropriate treatment. Erythema induratum is characterized by painful, erythematous, sometimes ulcerating nodules on the lower legs that, histopathologically, show a lobular panniculitis.

As such, the development and presentation of lesions fluctuate based on the underlying immune status of the host. Typically, lesions are tender but nonpruritic and may be precipitated by cold weather.

Currently, the CDC recommends a 6-month, four-drug course with 2 months or RIPE rifampin, isoniazid, pyrazinamide, ethambutolfollowed by 4 months of isoniazid. What you should be alert for in the history Erythema induratum also referred to as erythema induratum of Bazin EIB or nodular vasculitis is a chronic nodular skin disease that is thought to represent a hypersensitivity response to Mycobacterium tuberculosis or its antigens. You can help by adding to it. Papulonecrotic tuberculid differentiated clinically by the tendency toward lesion necrosis and subsequent crusting and histologically by location in the superficial dermis compared to the more characteristic location of EIB in the subcutaneous fat.

Patients are otherwise healthy without systemic symptoms and often present with a rash as the only symptom of their disease.